姓名：徐欢欢

职称：副教授

导师：硕士研究生导师

专业：化学生物学

邮箱：xuhuan1017@163.com

n 教育和工作简历

u 2009-09至2013-07，安徽工程大学，食品科学与工程，学士

u 2013-09至2016-06，云南农业大学，功能食品，硕士

u 2016-09至2019-06，云南农业大学，食品资源与营养工程，博士

u 2019-09至2022-09，云南农业大学，理学院，讲师

u 2022-10至今，云南农业大学，理学院，副教授

n 学术兼职

u 国家食药同源产业科技创新联盟茶产业专业委员会委员

n 教学工作

u 研究生课程：细胞及分子生物学实验技术

u 本科生课程：生物化学、分子生物学、仪器分析、科技论文写作

n 研究方向

u 化学生物学

u 功能食品

u 生物分子相互作用

n 管理服务工作

u 化学生物学专业负责人

u 转化营养与微生物工程博士研究生班班主任

u 20级应用化学1班学业导师

n 奖励与荣誉

u 2021-2022学年优秀本科生学业导师

u 云南农业大学2021年大学生暑期“三下乡”社会实践活动先进个人

n 研究项目

u 云南省科学技术厅，云南省基础研究计划面上项目，202101AT070749，科罗索酸通过干扰 RANKL-RANK相互作用改善骨质疏松症的分子机制，2022-04至2025-03，10万元，在研，主持

u 云南省科学技术厅，云南省农业基础研究联合专项面上项目，202101BD070001-034，TNF-α小分子抑制剂的筛选及其改善类风湿关节炎的作用机制，2022-01至2024-12，10万元，在研，主持

u 云南省科学技术厅，云南省基础研究计划青年项目，202101AU070086，EGCG阻断RANKL与其受体结合抑制破骨细胞生成的作用机制，2021-04至 2024-03，5万元，在研，主持

n 代表性论文

u Chunxia Gan#, Titi Liu#, Xiaorong Jia#, Xueqin Huang, Xiangdong Qin, Xuanjun Wang*, Jun Sheng*, Huanhuan Xu*, ATP supplementation suppresses UVB-induced photoaging in HaCaT cells via upregulation of expression of SIRT3 and SOD2, Skin Research and Technology, 2023;29:1–8. IF=2.240; 4区

u Huanhuan Xu#, Chunxia Gan#, Zemin Xiang#, Ting Xiang, Jin Li, Xueqin Huang, Xiangdong Qin, Titi Liu*, Jun Sheng*, Xuanjun Wang*, Targeting the TNF-α–TNFR interaction with EGCG to block NF-κB signaling in human synovial fibroblasts, Biomedicine & Pharmacotherapy 161 (2023) 114575. IF=7.419; 2区TOP

u Titi Liu#, Li Jiang#, Zemin Xiang#, Jin Li#, Yaqi Zhang, Ting Xiang, Wei Wang, Xiaofeng Li, Yuankan Jia, Xueqin Huang, Xiaofang Lu, Huanhuan Xu*, Xuanjun Wang*, Jun Sheng*, Tereticornate A suppresses RANKL-induced osteoclastogenesis via the downregulation of c-Src and TRAF6 and the inhibition of RANK signaling pathways, Biomedicine & Pharmacotherapy 151 (2022) 113140. IF=7.419; 2区TOP

u Huanhuan Xu#, Yuankan Jia#, Jin Li#, Xueqin Huang, Li Jiang, Ting Xiang, Yuanhao Xie, Xiaomei Yang, Titi Liu*, Zemin Xiang*, Jun Sheng*, Niloticin inhibits osteoclastogenesis by blocking RANKL–RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways, Biomedicine & Pharmacotherapy 149 (2022) 112902. IF=7.419; 2区TOP

u Huanhuan Xu#, Titi Liu#, Jin Li, Fei Chen, Jing Xu, Lihong Hu, Li Jiang, Zemin Xiang*, Xuanjun Wang*, Jun Sheng*, Roburic Acid Targets TNF to Inhibit the NF-κB Signaling Pathway and Suppress Human Colorectal Cancer Cell Growth, Frontiers in Immunology. 13 (2022):853165. IF=8.786; 2区TOP

u Huanhuan Xu#, Titi Liu#, Yuankan Jia, Jin Li, Li Jiang, Caijiang Hu, Xuanjun Wang*, Jun Sheng*, (-)-Epigallocatechin-3-gallate inhibits osteoclastogenesis by blocking RANKL–RANK interaction and suppressing NF-κB and MAPK signaling pathways, International Immunopharmacology. 95 (2021) 107464. IF=5.714; 2区

u Huanhuan Xu#, Jing Xu#, Fei Chen#, Titi Liu#, Jin Li#, Li Jiang, Yuankan Jia, Caijiang Hu, Ziqi Gao, Chunxia Gan, Lihong Hu, Xuanjun Wang*, Jun Sheng*, Acanthopanax senticosus aqueous extract ameliorates ovariectomy-induced bone loss in middle-aged mice by inhibiting the receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis, Food & Function, 2020, 11, 9696–9709. IF=5.396; 1区TOP

u Huanhuan Xu#, Lihong Hu#, Titi Liu#, Fei Chen, Jin Li, Jing Xu, Li Jiang, Zemin Xiang*, Xuanjun Wang*, Jun Sheng*, Caffeine Targets G6PDH to Disrupt Redox Homeostasis and Inhibit Renal Cell Carcinoma Proliferation, Frontiers in Cell and Developmental Biology. 8 (2020):556162. IF=6.684; 2区

u Huanhuan Xu#, Fei Chen#, Titi Liu#, Jing Xu, Jin Li, Li Jiang, Xuanjun Wang*, Jun Sheng*, Ellagic acid blocks RANKL–RANK interaction and suppresses RANKL-induced osteoclastogenesis by inhibiting RANK signaling pathways, Chemico-Biological Interactions. 331 (2020) 109235. IF=5.192; 3区

u Huanhuan Xu#, Chunxia Gan#, Ziqi Gao, Yewei Huang, Simin Wu, Dongying Zhang*, Xuanjun Wang*, Jun Sheng*, Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria, Frontiers in Cell and Developmental Biology. 8 (2020):822. IF=6.684; 2区

u Huanhuan Xu#, Litian Wang#, Boya Shi, Lihong Hu, Chunxia Gan, Ya Wang, Zemin Xiang*, Xuanjun Wang*, Jun Sheng*, Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation, Biomedicine & Pharmacotherapy. 129 (2020) 110441. IF=6.529; 2区

u Huanhuan Xu#, Titi Liu#, Jin Li#, Jing Xu, Fei Chen, Lihong Hu, Banglei Zhang, Chengting Zi*, Xuanjun Wang*, Jun Sheng*. Oxidation derivative of (-)-epigallocatechin-3-gallate (EGCG) inhibits RANKL-induced osteoclastogenesis by suppressing RANK signaling pathways in RAW 264.7 cells. Biomedicine & Pharmacotherapy. 118 (2019) 109237. IF=4.545; 3区

u Huanhuan Xu#, Titi Liu#, Jing Xu#, Jin Li, Fei Chen, Zemin Xiang, Yewei Huang, Dongying Zhang, Lihong Hu, Banglei Zhang, Chengting Zi*, Xuanjun Wang*, Jun Sheng*. Interactions between β-cyclodextrin and tea catechins, and potential anti-osteoclastogenesis activity of (-)-epigallocatechin-3-gallate-β-cyclodextrin complex. RSC Advances. 2019, 9, 28006–28018. IF=3.119; 3区

u Huanhuan Xu#, Titi Liu#, Lihong Hu, Jin Li, Chunxia Gan, Jing Xu, Fei Chen, Zemin Xiang*, Xuanjun Wang*, Jun Sheng*. Effect of caffeine on ovariectomy-induced osteoporosis in rats. Biomedicine & Pharmacotherapy. 112 (2019) 108650. IF=4.545; 3区

u Titi Liu#, Zemin Xiang#, Fei Chen, Dan Yin, Yewei Huang, Jing Xu, Lihong Hu, Huanhuan Xu*, Xuanjun Wang*, Jun Sheng*. Theabrownin suppresses in vitro osteoclastogenesis and prevents bone loss in ovariectomized rats. Biomedicine & Pharmacotherapy. 106 (2018) 1339-1347. IF=3.743; 3区

u Huanhuan Xu#, Dan Yin#, Titi Liu, Fei Chen, Yingli Chen*, Xuanjun Wang*, Jun Sheng*. Tea Polysaccharide Inhibits RANKL-Induced Osteoclastogenesis in RAW264.7 Cells and Ameliorates Ovariectomy-Induced Osteoporosis in Rats. Biomedicine & Pharmacotherapy. 102 (2018) 539-548. IF=3.743; 3区

u Titi Liu, Shihua Ding, Dan Yin, Xiangdan Cuan, Chuanqi Xie, Huanhuan Xu*, Xuanjun Wang*, Jun Sheng*. Pu-erh Tea Extract Ameliorates Ovariectomy-Induced Osteoporosis in Rats and Suppresses Osteoclastogenesis In Vitro. Frontiers in Pharmacology. 8 (2017):324. IF=3.831; 2区

u Huanhuan Xu#, Ya Wang#, Yana Chen, Pan Zhang, Yi Zhao, Yewei Huang*, Xuanjun Wang*, Jun Sheng*. Subcellular Localization of Galloylated Catechins in Tea Plant (Camellia sinensis (L.) O. Kuntze) Assessed via Immunohistochemistry. Frontiers in Plant Science. 7 (2016):728. IF=4.291; 2区

n 专利及标准

u 徐欢欢;刘提提;盛军;王宣军. 茶叶中酯型儿茶素含量检测试剂盒. 实用新型专利, 第18776156号

u 徐欢欢;刘提提;盛军;王宣军. 一种用于茶多酚溶液制备及酶促氧化的系统. 实用新型专利, 第18929617号

u 刘提提;徐欢欢;王宣军;盛军. 一种抗骨质疏松药物筛选试剂盒. 实用新型专利, 第18807495号

u 刘提提;徐欢欢;王宣军;盛军. 一种用于小鼠去势手术的固定装置. 实用新型专利, 第19132426号

n 学生工作

u 指导多名学生发表13篇SCI期刊论文

u 指导多名学生立项大创双创项目