应用化学系

字成庭


 

姓名:字成庭

职称:教授

导师:博士生导师

专业:化学

邮箱:zichengting@126.com

 

n 教育和工作简历

u 2020.10-至今,云南农业大学,教授,化学系

u 2018.01-2020.9,云南农业大学,副教授,化学系

u 2015.08-2017.12,云南农业大学,博士见习

n 学术兼职

u 中国化学学会会员

u 云南省微生物协会会员

u 食品安全风险评估委员

n 教学工作

u 研究生课程:食品营养学研究进展、细胞及分子生物学实验技术、现代食品营养学

u 本科生课程:有机化学、有机化学I、有机化学II、应化Seminar、有机化学实验、应用高分子化学、仪器分析实验、普通化学、普通化学实验

n 研究方向

u 农业化学基础研究及应用

u 食药同源化学物质基础及生物学功效

u 天然多糖化学生物学及其应用基础研究

n 管理服务工作

u 副院长

n 奖励与荣誉

u 云南省“兴滇英才”计划青年人才2020年)

n 研究项目

u 国家自然科学地区基金项目“新型铁皮石斛素类微管蛋白抑制剂的挖掘及作用机理研究”(编号31960075), 2020.012023.12, 项目负责人

u 国家自然科学基金青年项目表没食子儿茶素没食子酸酯(EGCG)氧化物的选择性合成、分离及抗肿瘤活性研究编号:21602196)2017.012019.12,项目负责人

u 南省农业联合专项重点项目“茶多酚纳米聚集体功能化TKIs的构建及其在靶向治疗非小细胞肺癌的应用研究(编号202101BD070001-028)2022.012024.12,项目负责人

u 云南省农业联合专项面上项目儿茶素类化合物的化学修饰对其生物利用度屏障的作用及机理研究”(编号2017FG001(-046)),2017.092020.08项目负责人

u 云南省自然科学基金青年项目“化学选择性EGCG偶联氧化产物的合成及抗肿瘤活性研究”( 编号:2017FD084),2017.06–2020.05,项目负责人

n 代表性论文

u Yan-Ping Huang#, Xiang-Dan Cuan#, Wei-wei Zhu, Xing-Ying Yang, Yun-Li Zhao, Jun Sheng, Cheng-Ting Zi*, Xuan-Jun Wang*. An EGCG Derivative in Combination with Nimotuzumab for the Treatment of Wild-Type EGFR NSCLC. Int. J. Mol. Sci. 2023, 24 (18), 14012.

u Jia-Min Xian#, Hong-Tao Hu#, Shu Yang#, Yu-Na Wang, Zhuo-Yi Wang, Ruo-Han Zhang, Cheng-Ting Zi*, Pei-Yuan Sun*, Jing Wang*. Inhibitory Effect of Magnolol on Activation of EGFR L858R/T790M/G796R. BJSTR., 2023, 50 (3), 41660-41666.

u Liu Yang#, ChengTing Zi#, Ding-Kang Chen, Jin-Yu Li, Rui He, Jiang-Miao Hu*. Target acquisition of anti-aging manno-oligosaccharide that triggers ECM process via TGF-β/Smads-SIRT1 signalling pathway. Carbohyd. Polym. 2022, 22, 120380.

u Cheng-Ting Zi#, Yin-Rong Xie#, Yun Niu#, Zhen-Hao Liu, Liu Yang, Yong-Kai Xi, Zhen-Jie Li, Feng-Mei Zhang, Ze-Min Xiang*, Jun Sheng*. Novel cannabidiol (CBD) derivatives: Synthesis, anti-inflammatory activity, and molecular docking. Phytochem. Lett. 2022, 51, 97103.

u Xiu-Li Sun#, Ze-Min Xiang#, Yin-Rong Xie#, Ning Zhang, Li-Xia Wang, Yi-Long Wu, Dong-Ying Zhang, Xuan-Jun Wang*, Jun Sheng*, Cheng-Ting Zi*. Dimeric-(-)-eigallocatechin-3-gallate inhibits the proliferation of lung cancer cells by inhibiting the EGFR signaling pathway. Chem-Biol. Interact. 2022, 365, 110084.

u Yan-Ping Huang#, Xiang-Dan Cuan#, Xing-Ying Yang, Wei-Wei Zhu, Yun-Li Zhao, Li Jiang, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Oxidized tea polyphenol (OTP-3) targets EGFR synergistic nimotuzumab at inhibition of non-small cell lung tumor growth. Bioorg. Chem. 2022, 128, 106084.

u Si-Si Chen#, Liu Yang#, Xia Qu#, Jin-Yu Li#, Cheng-Ting Zi, Hao Wang*, Jiang-Miao Hu*, Ye Liu*. A new polysaccharide platform constructs self-adjuvant nanovaccines to enhance immune responses. J. Nanobiotechnol. 2022, 20, 320.

u Ye-Wei Huang#, Jing-Yun Yan#, Xiu-Li Sun#, Yun Niu, Wen-Jun Yuan, Ling-Bin Kong, Xiang-Dong Qin, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Anticancer effects of dendrocandin (DDCD) against AKT in Hpeg2 cells using Molecular Modeling, DFT and in Vitro Study. Struct. Chem. 2022, 33, 13311340.

u Ning Zhang#, Yi-Long Wu#, Miao Qiao, Wen-Juan Yuan, Xing-Yu Li, Xuan-Jun Wang*, Jun Sheng*, Cheng-Ting Zi*. Structure–antioxidant activity relationships of dendrocandin analogues determined using density functional theory. Struct. Chem. 2022, 33, 795805.

u Li-Xia Wang#, Ze-Hao Wang, Xiu-Li Sun, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Discovery of EGFR-Targeted Environment-Sensitive Fluorescent Probes for Cell Imaging and Efficient Tumor Detection. Bioorg. Chem. 2022. 121, 105585.Published: 2022-01-04

u Ya Wang#, Xiao-Jing Shen#, Fa-Wu Su#, Yin-Rong Xie, Li-Xia Wang, Ning Zhang, Yi-Long Wu , Yun Niu, Dong-Ying Zhang, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng. Novel per-butyrylated glucoses derivatives of (-)-epigallocatechin-3-gallate inhibit cancer cells proliferation by decreasing phosphorylation of the EGFR: Synthesis, cytotoxicity and molecular docking. Molecules. 2021, 26 (14) 4361.

u Cheng-Ting Zi#, Ze-Hao Wang#, Jing Shi#, Boya Shi, Ning Zhang, Yi-Ling Wu, Yin-Rong Xie, Lu Zhou, Chun Xiao*, Xuan-Jun Wang*, Jun Sheng*. Synthesis, cytotoxicity and molecular docking of methylated (-)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin derivatives as novel antitumor agents. J. Chem. Res. 2021:17.

u Ze-Hao Wang#, Li-Xia Wang#, Bo-Ya Shi, Xiu-Li Sun, Yin-Rong Xie, Hao-Nan Yang, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Demethyleneberberine promotes apoptosis and suppresses TGF-β/Smads induced EMT in the colon cancer cells HCT-116. Cell Biochem. Fun. 2021: 18.

u Bo-Ya Shi#, Ze-Hao Wang#, Ning Zhang, Yin-Rong Xie, Xiu-Li Sun, Hao-Nan Yang, Yi-Long Wu, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Synthesis and Anticancer Activity of Glucosylated novel (-)-Epigallocatechin-3-gallate Derivatives Linked via Triazole Rings. Med. Chem. Res. 2021, 30: 12401248.

u Jing-Yun Yan#, Hao-Nan Yang#, Ning Yang, Yin-Rong Xie, Xiu-Li Sun, Ye-Wei Huang, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Synthesis and in vitro biological evaluation of novel dendrocandin analogue as potential anti-tumor agent. Nat. Prod. Res. 2021:16.

u Boya Shi, Zehao Wang, Xuanjun Wang, Jun Sheng*, Chengting Zi*. Recent progress of small-molecule epidermal growth factor receptor (EGFR) inhibitors. Med. Res. 20202020, 4 (200011), 1–4.

u Canpeng Li#, Yuxun Lu#, Chengting Zi#, Yuting Zhao, Hui Zhao*, Yaping Zhang*. Cationic pillar[6]arene induces cell apoptosis by inhibiting protein tyrosine phosphorylation via host-guest recognition. Int. J. Mol. Sci. 2020, 21, 7949.

u Chengting Zi#, Liu Yang#, Yue Hu, Pan Zhang, Han Tang, Banglei Zhang, Xiaojing Shen, Qinghua Kong, Ya Wang*, Xuanjun Wang*, Jun Sheng*. Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates. J. Asin Nat. Prod. Res. 2021, 23 (8), 772-780.

u Chengting Zi#, Peiyuan Sun#, Ning Zhang, Han Tang, Haonan Yang, Qi Wang, Yuna Wang, Jing Wang*, Xuanjun Wang*, Jun Sheng*. Glucosylated (-)-Epigallocatechin-3-gallate (EGCG) derivative via triazole ring: Synthesis and combined with cisplatin/paclitaxel inhibits NSCLC cancer cells by decreasing phosphorylation of the EGFR. J. Chem. Res. 2020, 44 (9-10) 586591.

u Yuna Wang#, Jing Wang#, Hao-Nan Yang, Bang-Lei Zhang, Pan Zhang, Pei-Yuan Sun, Ning Zhang, Ya Wang, Jun Sheng*, Xuan-Jun Wang*, Cheng-Ting Zi*. The oxidation of (-)-epigallocatechin-3-gallate inhibits T-Cell Acute Lymphoblastic Leukemia cell line HPB-ALL via the regulation of Notch1 expression. RSC Adv. 2020, 10, 16791684.

n 代表性著作

u 参编《有机化学

u 参编《普通化学与定量分析化学学习指导及习题解答》等书

n 专利及标准

u 盛军,王宣军,字成庭,王晶,向泽敏,黄业伟,王娅,吴晓云,方崇业,刘佳,张冬英,汪琦,唐晗,张帮磊,王玉娜.表没食子儿茶素没食子酸酯糖苷衍生物及其应用,专利公开号:CN201810094218.6

u 盛军,王宣军,黄艳苹,字成庭,向泽敏,黄业伟,赵云丽,爨向丹,徐欢欢,罗瑞. 表没食子儿茶素没食子酸酯糖苷衍生物及其应用,专利公开号:CN 110038006 A

u 字成庭,盛军,王宣军,燕静云,杨豪男,张帮磊,胡月,杨宁,张宁,吴以龙.铁皮石斛素类似物及其制备方法和用途.专利公开号:CN 112266377 A

u 字成庭,盛军,王宣军,张宁,杨豪男,袁文娟,乔妙,孙秀丽.一种铁皮石斛素及其制备方法.专利公开号:CN 113045536

u 盛军,字成庭,王宣军,袁文娟,孙秀丽,张帮磊,杨豪男,谢引荣,燕静云,胡月,张宁,杨宁.铁皮石斛素及其制备抗癌药物的应用.专利公开号:CN 112979608 A

u 盛军,字成庭,王宣军,袁文娟,孙秀丽,谢引荣,杨豪男,王丽霞,张宁,吴以龙,施博雅,王泽昊.铁皮石斛素及其用途.专利公开号:CN 112939928 A

u 字成庭盛军王宣军张宁吴以龙.一种用于电化学工作站检测的多功能电解池.专利号:ZL 2020 2 2833997.2申请时间:2020.12.01授权时间:2021.10.19

u字成庭盛军王宣军吴以龙张宁.一种用于分离茶多糖和聚合多酚的装置.专利号:ZL 2020 2 3008416.8

n 学生工作

u 指导已经毕业研究生5名,在读研究生5名,发表论文22篇。

u 指导本科生30名,本科生与发表科研论文8篇。